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1

ChemInform Abstract: Emerging Molecular Approaches to Pain Therapy

Michael Williams, Elizabeth A. Kowaluk, Stephen P. Arneric

Journal:

Year:

1999

File:

PDF, 24 KB

1999

2

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Robert J. Cherney, Li Wang, Dayton T. Meyer, Chu-Biao Xue, Elizabeth C. Arner, Robert A. Copeland, Maryanne B. Covington, Karl D. Hardman, Zelda R. Wasserman, Bruce D. Jaffee, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 290 KB

english, 1999

3

Identification of fibronectin neoepitopes present in human osteoarthritic cartilage

Marc D. Zack, Elizabeth C. Arner, Charles P. Anglin, James T. Alston, Anne-Marie Malfait, Micky D. Tortorella

Journal:

Arthritis & Rheumatism

Year:

2006

Language:

english

File:

PDF, 597 KB

english, 2006

4

Effect of animal age and chronicity of interleukin-1 exposure on cartilage proteoglycan depletion in vivo

Dr. Elizabeth C. Arner

Journal:

Journal of Orthopaedic Research

Year:

1994

Language:

english

File:

PDF, 799 KB

english, 1994

5

Aggrecanase-mediated cartilage degradation

Elizabeth C Arner

Journal:

Current Opinion in Pharmacology

Year:

2002

Language:

english

File:

PDF, 111 KB

english, 2002

6

Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

Elizabeth C. Arner, Clare E. Hughes, Carl P. Decicco, Bruce Caterson, Micky D. Tortorella

Journal:

Osteoarthritis and Cartilage

Year:

1998

Language:

english

File:

PDF, 392 KB

english, 1998

7

Evolution of a matrix metalloproteinase assay to assess inhibitor potency and selectivity

Trzaskos, James, Pratta, Michael, Blessington, Dianna, Arner, Elizabeth, Williams, Jean, Giannaras, John, Copeland, Robert A, Dowling, Randi, Lombardo, Diane, Decicco, Carl

Journal:

Acta Orthopaedica Scandinavica

Year:

1995

File:

PDF, 389 KB

1995

8

2,5-Diarylisothiazolone: novel inhibitors of cytokine-induced cartilage destruction

Stephen W. Wright, Joseph J. Petraitis, Bruce Freimark, John V. Giannaras, Michael A. Pratta, Susan R. Sherk, Jean M. Williams, Ronald L. Magolda, Elizabeth C. Arner

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 746 KB

english, 1996

9

Isothiazolones interfere with normal matrix metalloproteinase activation and inhibit cartilage proteoglycan degradation

ARNER, Elizabeth C, PRATTA, Michael A, FREIMARK, Bruce, LISCHWE, Michael, TRZASKOS, James M, MAGOLDA, Ronald L, WRIGHT, Stephen W

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 503 KB

english, 1996

10

Emerging Molecular Approaches to Pain Therapy

Williams, Michael, Kowaluk, Elizabeth A., Arneric, Stephen P.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 931 KB

english, 1999

11

Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture

Elizabeth C. Arner, Michael A. Pratta

Journal:

Arthritis & Rheumatism

Year:

1989

Language:

english

File:

PDF, 812 KB

english, 1989

12

Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4)

Micky D. Tortorella, Rui-Qin Liu, Timothy Burn, Robert C. Newton, Elizabeth Arner

Journal:

Year:

2002

Language:

english

File:

PDF, 1006 KB

english, 2002

13

Design and Synthesis of a Series of (2 R )- N 4 -Hydroxy-2-(3-hydroxybenzyl)- N 1 - [(1 S ,2 R )-2-hydroxy-2,3-dihydro-1 H -inden- 1-yl]butanediamide Derivatives as Potent, Selective, and Orally Bioavailable Aggrecanase Inhibitors †

Yao, Wenqing, Wasserman, Zelda R., Chao, Michael, Reddy, Gade, Shi, Eric, Liu, Rui-Qin, Covington, Maryanne B., Arner, Elizabeth C., Pratta, Michael A., Tortorella, Micky, Magolda, Ronald L., Newton,

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 82 KB

english, 2001

14

Opportunities in pain therapy:beyond the opioids and NSAIDs

Kowaluk, Elizabeth A, Arneric, Stephen P, Williams, Michael

Journal:

Expert Opinion on Emerging Drugs

Year:

1998

Language:

english

File:

PDF, 1.49 MB

english, 1998

15

P1, P2′-Linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

James J.-W. Duan, Lihua Chen, Chu-Biao Xue, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Robert R. Cope, Elizabeth C. Arner, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 292 KB

english, 1999

16

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) is induced in rabbit articular chondrocytes by cotreatment with interleukin 1β and a protein kinase C activator

Yutaka Ogata, Michael A. Pratta, Hideaki Nagase, Elizabeth C. Arner

Journal:

Experimental Cell Research

Year:

1992

Language:

english

File:

PDF, 1.65 MB

english, 1992

17

Host metalloproteinases in Lyme arthritis

Linden T. Hu, Manuel A. Eskildsen, Catherine Masgala, Allen C. Steere, Elizabeth C. Arner, Michael A. Pratta, Alan J. Grodzinsky, Andrew Loening, George Perides

Journal:

Arthritis & Rheumatism

Year:

2001

Language:

english

File:

PDF, 684 KB

english, 2001

18

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5

Ruo-Hua Song, Micky D. Tortorella, Anne-Marie Malfait, James T. Alston, Zhiyong Yang, Elizabeth C. Arner, David W. Griggs

Journal:

Arthritis & Rheumatism

Year:

2007

Language:

english

File:

PDF, 403 KB

english, 2007

19

Chondrocyte Extracellular Matrix Synthesis and Turnover Are Influenced by Static Compression in a New Alginate Disk Culture System

Paula M. Ragan, Vicki I. Chin, Han-Hwa K. Hung, Koichi Masuda, Eugene J.-M.A. Thonar, Elizabeth C. Arner, Alan J. Grodzinsky, John D. Sandy

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 147 KB

english, 2000

20

Substrate-Dependent Inhibition Kinetics of an Active Site-Directed Inhibitor of ADAMTS-4 (Aggrecanase 1)

Wittwer, Arthur J., Hills, Robert L., Keith, Robert H., Munie, Grace E., Arner, Elizabeth C., Anglin, Charles P., Malfait, Anne-Marie, Tortorella, Micky D.

Journal:

Year:

2007

Language:

english

File:

PDF, 174 KB

english, 2007

21

ChemInform Abstract: P1,P2′-Linked Macrocyclic Amine Derivatives as Matrix Metalloproteinase Inhibitors.

James J.-W. Duan, Lihua Chen, Chu-Biao Xue, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Robert R. Copeland, Elizabeth C. Arner, Carl P. Decicco

Journal:

Year:

1999

File:

PDF, 37 KB

1999

22

The Effects of IL-1 on Mitogen-Activated Protein Kinases in Rabbit Articular Chondrocytes

Peggy A. Scherle, Michael A. Pratta, Wendi S. Feeser, Elizabeth J. Tancula, Elizabeth C. Arner

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 142 KB

english, 1997

23

Proprotein convertase activation of aggrecanases in cartilage in situ

Anne-Marie Malfait, Elizabeth C. Arner, Ruo-Hua Song, James T. Alston, Stella Markosyan, Nicholas Staten, Zhiyong Yang, David W. Griggs, Micky D. Tortorella

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

24

ADAMTS-4 (aggrecanase-1): N-Terminal activation mechanisms

Micky D. Tortorella, Elizabeth C. Arner, Robert Hills, Jennifer Gormley, Kam Fok, Lyle Pegg, Grace Munie, Anne-Marie Malfait

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 302 KB

english, 2005

25

Effect of interleukin-1 on the size distribution of cartilage proteoglycans as determined by sedimentation field flow fractionation

Arner, Elizabeth C., Kirkland, Joseph J.

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1989

Language:

english

File:

PDF, 559 KB

english, 1989

26

Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

ELIZABETH C. ARNER, MICHAEL A. PRATTA, CARL P. DECICCO, CHU-BIAO XUE, ROBERT C. NEWTON, JAMES M. TRZASKOS, RONALD L. MAGOLDA, MICKY D. TORTERELLA

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.06 MB

english, 1999

27

Medical Diary

Arner, Elizabeth C., Kirkland, Joseph J.

Journal:

Year:

1936

Language:

english

File:

PDF, 188 KB

english, 1936

28

Accelerating drug development for Alzheimer's disease through the use of data standards

Neville, Jon, Kopko, Steve, Romero, Klaus, Corrigan, Brian, Stafford, Bob, LeRoy, Elizabeth, Broadbent, Steve, Cisneroz, Martin, Wilson, Ethan, Reiman, Eric, Vanderstichele, Hugo, Arnerić, Stephen P.,

Journal:

Alzheimer s & Dementia Translational Research & Clinical Interventions

Year:

2017

Language:

english

File:

PDF, 1.23 MB

english, 2017

29

Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

Robert J. Cherney, Carl P. Decicco, David J. Nelson, Li Wang, Dayton T. Meyer, Karl D. Hardman, Robert A. Copeland, Elizabeth C. Arner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 301 KB

english, 1997

30

Interleukin-1β stimulates phospholipase A2 mRNA synthesis in rabbit articular chondrocytes

Bernadette Lyons-Giordano, Gary L. Davis, William Galbraith, Michael A. Pratta, Elizabeth C. Arner

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 1.18 MB

english, 1989

31

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Robert J Cherney, Ruowei Mo, Dayton T Meyer, Li Wang, Wenqing Yao, Zelda R Wasserman, Rui-Qin Liu, Maryanne B Covington, Micky D Tortorella, Elizabeth C Arner, Mingxin Qian, David D Christ, James M Tr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

32

Opportunities in pain therapy:beyond the opioids and NSAIDs

Kowaluk, Elizabeth A, Arneric, Stephen P, Williams, Michael

Journal:

Expert Opinion on Emerging Drugs

Year:

1998

File:

PDF, 1.49 MB

1998

33

Modulation of interleukin-1–induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C

Elizabeth C. Arner, Michael A. Pratta

Journal:

Arthritis & Rheumatism

Year:

1991

Language:

english

File:

PDF, 709 KB

english, 1991

34

Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics

Carl P Decicco, Jennifer L Seng, Kenneth E Kennedy, Maryanne B Covington, Patty K Welch, Elizabeth C Arner, Ronald L Magolda, David J Nelson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

35

Eicosanoid production and cell accumulation induced by intrapleural injection of sodium arachidonate in the rat. Characterization of the model

Kathleen R. Gans, Susan R. Lundy, Elizabeth C. Arner, Deborah A. Munzer, Randine L. Dowling, William Galbraith

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 414 KB

english, 1989

36

Long-Term Nitrogen Dioxide Exposure

Arner, Elizabeth C., Rhoades, Rodney A.

Journal:

Archives of Environmental Health An International Journal

Year:

1973

Language:

english

File:

PDF, 3.39 MB

english, 1973

37

Inhibition of cartilage degradation by isothiazoloquinolinones

William H. Miller, Donald J.P. Pinto, Robert J. McHugh Jr., Elizabeth C. Arner, Michael A. Pratta, Ronald L. Magolda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 297 KB

english, 1994

38

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Irina C. Jacobson, Prabhakar G. Reddy, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Elizabeth C. Arner, Robert A. Copeland, Carl P. Decicco, Ronald L. Magolda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 256 KB

english, 1998

39

Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors

Cherney, Robert J., Wang, Li, Meyer, Dayton T., Xue, Chu-Baio, Wasserman, Zelda R., Hardman, Karl D., Welch, Patty K., Covington, Maryanne B., Copeland, Robert A., Arner, Elizabeth C., DeGrado, Willia

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 76 KB

english, 1998

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